Sunday, September 30, 2012

Bangladeshi Muslims torch Buddhist temples, homes

A Buddha statue stands amidts the ruins of a Buddhist temple that was torched in Ramu in the coastal district of Cox's Bazar, Bangladesh, Sunday, Sept. 30, 2012. Thousands of Bangladeshi Muslims angry over an alleged derogatory photo of the Islamic holy book Quran on Facebook set fires in at least 10 Buddhist temples and 40 homes near the southern border with Myanmar, authorities said Sunday. (AP Photo)

A Buddha statue stands amidts the ruins of a Buddhist temple that was torched in Ramu in the coastal district of Cox's Bazar, Bangladesh, Sunday, Sept. 30, 2012. Thousands of Bangladeshi Muslims angry over an alleged derogatory photo of the Islamic holy book Quran on Facebook set fires in at least 10 Buddhist temples and 40 homes near the southern border with Myanmar, authorities said Sunday. (AP Photo)

Damaged statues at a Buddhist temple that was torched in Ramu in the coastal district of Cox's Bazar, Bangladesh, Sunday, Sept. 30, 2012. Thousands of Bangladeshi Muslims angry over an alleged derogatory photo of the Islamic holy book Quran on Facebook set fires in at least 10 Buddhist temples and 40 homes near the southern border with Myanmar, authorities said Sunday. (AP Photo)

Smoke rises from the remains of a Buddhist temple that was torched in Ramu in the coastal district of Cox's Bazar, Bangladesh, Sunday, Sept. 30, 2012. Thousands of Bangladeshi Muslims angry over an alleged derogatory photo of the Islamic holy book Quran on Facebook set fires in at least 10 Buddhist temples and 40 homes near the southern border with Myanmar, authorities said Sunday. (AP Photo)

Bangladeshi Buddhist monks stage a protest in Chittagong, Bangladesh, Sunday, Sept. 30, 2012 after Muslims torched Buddhist temples in southern Bangladesh. Thousands of Bangladeshi Muslims angry over an alleged derogatory photo of the Islamic holy book Quran on Facebook set fires in at least 10 Buddhist temples and 40 homes near the southern border with Myanmar, authorities said Sunday. (AP Photo)

Damaged statues at a Buddhist temple that was torched in Ramu in the coastal district of Cox's Bazar, Bangladesh, Sunday, Sept. 30, 2012. Thousands of Bangladeshi Muslims angry over an alleged derogatory photo of the Islamic holy book Quran on Facebook set fires in at least 10 Buddhist temples and 40 homes near the southern border with Myanmar, authorities said Sunday. (AP Photo)

COX'S BAZAR, Bangladesh (AP) ? Thousands of Bangladeshi Muslims set fire to at least 10 Buddhist temples and 40 homes in anger over a Facebook photo of a burned Quran before authorities restored order.

The situation was under control Sunday afternoon after extra security officers were deployed and the government banned public gatherings in the troubled areas near the southern border with Myanmar, said Nojibul Islam, a police chief in the coastal district of Cox's Bazar.

He said at least 20 people were injured in the attacks that started late Saturday after a photo of a burned copy of the Muslim holy book was posted on Facebook. The rioters blamed the photo on a local Buddhist boy, though it was not immediately clear if he actually posted the photo.

Bangladesh's popular English-language Daily Star newspaper quoted the boy as saying that the photo was mistakenly tagged on his Facebook profile. The newspaper reported that soon after the violence started, the boy's Facebook account was closed and police escorted him and his mother to safety.

Joinul Bari, chief government administrator in Cox's Bazar district, said authorities detained the boy's parents and were investigating.

Buddhists make up less than 1 percent of Muslim-majority Bangladesh's 150 million people.

The Bangladeshi violence follows protests that erupted in Muslim countries over the past month after a low-budget film, "Innocence of Muslims," produced by a U.S. citizen denigrated the Prophet Muhammad by portraying Islam's holiest figure as a fraud, womanizer and child molester.

Some two dozen demonstrators have been killed in protests that attacked symbols of U.S. and the West, including diplomatic compounds.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-09-30-Bangladesh-Temples%20Torched/id-9d08246c181f475f8ac030364fac46e1

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Claims Representative - Workers Compensation job from Insurance ...

Claims Representative - Workers Compensation

CLAIM YOUR FUTURE AS A GREAT PERFORMER!

Providing both satisfying and challenging work along with a highly professional and friendly work atmosphere, Sedgwick has a strong commitment to its colleagues and its clients. If you are seeking place where you can do great things for those whose lives you touch while maximizing your own career possibilities, Sedgwick is the place for you. As the largest and most innovative Third Party Administrator in the claims industry and the first and only TPA to receive both recognition as the Best TPA in America and the coveted Employer of Choice designation, we invite you to come be a part of our team and, ?Claim Your Future.?

PRIMARY PURPOSE : To analyze mid- and higher-level workers compensation claims to determine benefits due; to ensure ongoing adjudication of claims within company standards and industry best practices; and to identify subrogation of claims and negotiate settlements.

ESSENTIAL FUNCTIONS and RESPONSIBILITIES


  • Manages workers compensation claims determining compensability and benefits due on long term indemnity claims, monitors reserve accuracy, and files necessary documentation with state agency.
  • Develops and manages workers compensation claims' action plans to resolution, coordinates return-to-work efforts, and approves claim payments.
  • Approves and processes assigned disability claims, determines benefits due, and manages action plan pursuant to the disability claim or client contract.
  • Manages subrogation of claims and negotiates settlements.
  • Communicates claim action with claimant and client.
  • Ensures claim files are properly documented and claims coding is correct.
  • May process complex lifetime medical and/or defined period medical claims which include state and physician filings and decisions on appropriate treatments recommended by utilization review.
  • Maintains professional client relationships.
  • ADDITIONAL FUNCTIONS and RESPONSIBILITIES


  • Performs other duties as assigned.
  • Supports the organization's quality program(s).
  • Travels as required.
  • QUALIFICATION

    Education & Licensing
    Baccalaureate degree from an accredited college or university preferred.

    Experience
    Three (3) years of claims management experience or successful completion of Claims Examiner II training required. Licenses as required.

    Skills & Knowledge


    • Knowledge of regulations, offsets and deductions, disability duration, medical management practices and Social Security and Medicare application procedure as applicable to line of business
    • Excellent oral and written communication, including presentation skills
    • PC literate, including Microsoft Office products
    • Analytical and interpretive skills
    • Strong organizational skills
    • Good interpersonal skills
    • Ability to work in a team environment
    • Ability to meet or exceed Service Expectations

    WORK ENVIRONMENT
    When applicable and appropriate, consideration will be given to reasonable accommodations.

    Mental: Clear and conceptual thinking ability; excellent judgment, troubleshooting, problem solving, analysis, and discretion; ability to handle work-related stress; ability to handle multiple priorities simultaneously; and ability to meet deadlines

    Physical: Computer keyboarding, travel as required

    Auditory/Visual: Hearing, vision and talking

    NOTE : Credit security clearance, confirmed via a background credit check, is required for this position.

    The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time.


    Sedgwick is an Equal Opportunity Employer

    and a

    Drug-Free Workplace


    Additional Information: N/A
    Requisition #: 10166

    Source: http://jobs.insuranceclaimsweb.com/c/job.cfm?site_id=1635&jb=11060850

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    Making Strides Against Breast Cancer walk to be held Oct. 6 at JBPHH

    Brandon Bosworth
    Contributing Writer

    The 2012 Making Strides Against Breast Cancer walk takes place starting at 7 a.m., Oct. 6, at Richardson Field, Joint Base Pearl Harbor-Hickam.

    This event is part of the American Cancer Society?s nationwide series of walking events to raise funds and awareness to end breast cancer. Nationwide, more than 270 Making Strides walks occur each year, ranging in distance from 3 to 5 miles.

    In 1984, cancer survivor Margery Gould Rath and a group of volunteers held the first Making Strides Against Cancer in Boston. The goal was to cele brate fellow cancer survivors by raising funds for the American Cancer Society. The first walk drew 200 participants and soon become a Boston tradition.

    In 1993, the event officially became known as the American Cancer Society Making Strides Against Breast Cancer. Since then, 8 million walkers across the United States have raised more than $460 million to help fight breast cancer through Making Strides events. In 2011 alone, 1 million walkers across the country collected more than $60 million to help fight the disease.

    The American Cancer Society is looking for volunteers and participants for the Oct. 6 event. For more information, visit the website MakingStridesHonolulu.org or call 432-9133.

    Category: Life & Leisure

    Source: http://www.hookelenews.com/making-strides-against-breast-cancer-walk-to-be-held-oct-6-at-jbphh/

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    Saturday, September 29, 2012

    Breast Cancer Awareness 2012 - Shape Magazine

    Sorry, Readability was unable to parse this page for content.

    Source: http://www.shape.com/lifestyle/mind-and-body/breast-cancer-awareness-2012

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    Fighting in Syria starts fire in medieval souks

    BEIRUT (AP) ? Syrian rebels and residents of Aleppo struggled Saturday to contain a huge fire that destroyed parts of the city's medieval souks, or markets, following raging battles between government troops and opposition fighters there, activists said.

    Some described the overnight blaze as the worst blow yet to a historic district that helped make the heart of Aleppo, Syria's largest city and commercial hub, a UNESCO world heritage site.

    The labyrinth of narrow alleys lined with shops was once a major tourist attraction, but has been the scene of near-daily firefights and shelling in recent weeks after rebels who fought their way into the city two months ago pushed toward its center.

    Amateur footage posted online by activists showed raging orange flames licking the wooden doors of shops as the wood crackled, and rebels using a small water hose as they struggled to put out the fire. Other videos showed a pall of smoke hanging over the city's skyline.

    The fire started late Friday amid heavy government shelling and was still burning Saturday morning, activists said.

    One Aleppo-based activist, Ahmad al-Halabi, estimated the blaze destroyed a majority of the shops in the district.

    "It's a disaster. The fire is threatening to spread to remaining shops," said al-Halabi, speaking from the stricken area by telephone. He claimed Syrian authorities cut the water supply off the city, making it more difficult to put out the flames. He said rebels and civilians were working together to control the blaze with a limited number of fire extinguishers.

    "It is a very difficult and tragic situation there," he said.

    Once considered a bastion of support for Syrian President Bashar Assad's regime, Aleppo has in the last two months become the focus of the insurgency. Its fall would give the opposition a major strategic victory, with a stronghold in the north near the Turkish border.

    Since the rebel offensive began in August, each side has controlled about half of the city and has repeatedly tried ? but failed ? to capture the rest.

    Rebels launched Thursday what they said would be a "decisive battle" to drive Assad's forces out of Aleppo and fighting has since spread to wide swaths of the city.

    The souks of Aleppo ? a maze of vaulted passageways with shops that sell everything from foods, fabrics, perfumes, spices and artisan souvenirs ? are a tactical prize for the combatants. They lie beneath the city's towering citadel where activists say regime troops and snipers have taken up positions.

    Many of the shops have wooden doors, and clothes, fabrics and leather wares inside helped spread the fire, activists said.

    The Aleppo souks are not the only Syrian cultural treasures to have fallen victim to the chaos of the country's uprising and the crackdown by the Assad regime.

    Some of the country's most significant sites, including centuries-old fortresses, have been caught in the crossfire in battles between regime forces and rebels. Others have been turned into military bases, raising archaeologists' fears of damage.

    Regime shelling of neighborhoods where the opposition is holed up has smashed historic mosques, churches and souks in the central Homs province and elsewhere the country. Looters have stolen artifacts from excavations and museums.

    Rami Abdul-Rahman, who heads the Syrian Observatory, said it was not clear how the fire at the Aleppo market was started but also said a large part of the souks have been destroyed. The group relies on a wide network of activists on the ground.

    The claims could not be independently verified because of limitations on the work of journalists in Syria.

    Fighting continued in many parts of Aleppo Saturday and activists said at least three people were killed, including two rebel fighters. Syria's state-run news agency SANA said soldiers were pursuing military operations against armed groups in Aleppo and its outskirts, inflicting heavy losses on the "terrorists," the term used by authorities to refer to rebels.

    In the Damascus suburb of Qudsaya, activists said the bodies of at least eight men were found who appeared to have been summarily executed, but the circumstances were not immediately clear.

    The Syrian uprising began in March 2011 with largely peaceful protests but has since transformed into an insurgency and civil war that has defied all attempts at a diplomatic solution. Activists say more than 30,000 people have been killed.

    Source: http://news.yahoo.com/fighting-syria-starts-fire-medieval-souks-094520625.html

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    This year's flu vaccine guards against new strains

    (AP) ? Time to get your flu vaccine. And remember: Last year's shot won't protect you this year.

    Federal health authorities said Thursday that this year's vaccine contains protection against two different strains that have begun circling the globe. And just because flu was mild last winter, doesn't mean it won't bounce back with its usual ferocity this winter.

    With 135 million doses expected, there's plenty of vaccine to go around.

    Flu vaccination is recommended for virtually everyone older than 6 months of age. But the government says just 42 percent of Americans were immunized last year.

    The good news is that three-quarters of babies and toddlers were vaccinated. But even though people 65 and older also are at very high risk, just two-thirds were vaccinated.

    Associated Press

    Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-09-27-Flu%20Vaccine/id-9d17b46fb2ab4f61b480afe67c600d4c

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    Thursday, September 27, 2012

    Mothers in trouble even in Germany - West

    Mothers in trouble even in Germany

    In Germany, motherhood is expensive. Not only for the inevitable costs related to a child, but for the impact of the baby on the mother?s salary. According to a study by the Hochschul Information System, which considered a sample of about 5,500 people with degrees in ten years after graduation to study, women without children earn about 20 thousand Euro per year more than mothers (50,478 against 30,882). The reason? Who has a child undergoes an interruption of employment, often can only work part-time and rarely occupies an important position. So much so that 40% of women without children said that they have given up to a family in order not to stifle the career. However, things go differently for men: German male workers are not affected by the influence of parenthood on wages and ? with or without children ? earn almost the same amount.

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    Source: http://www.west-info.eu/germany-family-career-women-children-salary/

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    Tuesday, September 25, 2012

    'Homeland' and 'Modern Family' win big at Emmys - Home ? Other ...

    LOS ANGELES (AP) ? The terrorism thriller "Homeland" and "Modern Family" were the top winners at Sunday's Emmy Awards in a ceremony that veered between daring and predictability in honors and Jimmy Kimmel's turn as host.

    The four awards for "Modern Family" included a three-peat as best comedy series, although there was a minor backlash online as some Emmy watchers questioned whether the show had a deserving season. "Mad Men" walked away without a single statuette.

    "Homeland," whose four trophies included honors for stars Claire Danes and Damian Lewis, stopped "Mad Men" in its tracks, denying the show a record-setting fifth best drama trophy. Turns out the TV academy wasn't ready to crown the Madison Avenue saga as best ever.

    Showtime's "Homeland," the cable channel's first best drama winner, also kept Bryan Cranston from his fourth consecutive best acting award for "Breaking Bad" and made "Mad Men" star Jon Hamm an also-ran once more.

    "I'm one of those pesky Brits, I apologize," said Lewis, who plays an American. "I don't really believe in judging art, but I thought I'd show up just in case."

    Danes, eye-catching in a bright yellow dress that gracefully draped the pregnant actress, was effusive.

    "My husband, my love, my life, my baby daddy, this doesn't mean anything without you," she said to her spouse, actor Hugh Dancy.

    Backstage, Danes said she particularly appreciated one fan: President Barack Obama has said he's a fan of "Homeland," about a Marine and former POW who's suspected of working for al Qaeda.

    "No pressure," the actress said. "It's way cool that he is a fan. It speaks to the relevancy of the show and it's hugely validating."

    The acting trophies, along with a best writing award for the show, gave "Homeland" momentum as it headed toward the best drama award.

    Kimmel, in his first turn as Emmy host, fielded some clever videos (no surprise given the famed Matt Damon-Sarah Silverman romp he inspired) but wasn't memorable on stage as the three-hour ceremony unfolded.

    Aaron Paul won best supporting drama actor for "Breaking Bad" and "Homeland" won the best writing award.

    "Thank you so much for not killing me off," Paul said of his drug-dealing character's lucky survival. "Thank you Hollywood for allowing me to be part of your group," he added, noting he'd moved from Idaho to pursue his dreams.

    In a surprise on the comedy side, Emmy voters decided that "Two and a Half Men" with Jon Cryer and without Charlie Sheen is really good, as Cryer claimed the best comedy actor trophy.

    "Don't panic, people. Something has clearly gone terribly wrong. I'm stunned," said Cryer, who on the red carpet before the show has expressed confidence he wouldn't win. Among others, he beat out two-time winner Jim Parsons of "The Big Bang Theory."

    Ashton Kutcher, who joined the show after Sheen was fired, wasn't nominated.

    Julia Louis-Dreyfus was honored as best actress in comedy for "Veep."

    Andy Griffith topped a segment honoring industry members who died during the previous year. Ron Howard, who played Griffith's son Opie in "The Andy Griffith Show," said he belonged "in the pantheon."

    "Dang if he didn't make it look powerful easy while he was going about it," Howard said.

    Phyllis Diller, Davy Jones of "The Monkees," Sheman Hemsley and Richard Dawson were among the others honored in a montage.

    Earlier in the show, Kimmel dared to mock the in memorian package that typically airs at awards shows with one showing him in various guises. Josh Groban sang a mournful "You're Beautiful" in background.

    "I will be missed," Kimmel said.

    Perhaps Kimmel's most notable achievement was a prank: Inviting "30 Rock" star Tracy Morgan to lie on the stage, then asking viewers to post on Facebook and tweet that Morgan "just passed out" and turn on ABC right now to see it. It worked, with the message going viral and maybe even boosting the Emmy audience for a few moments.

    Maggie Smith was honored as best supporting drama actress for her tart-tongued dowager in "Downton Abbey," unhurt by the program's move from the miniseries category.

    "Homeland," the domestic espionage thriller, won the best drama writing award.

    "Modern Family" made it look easy as the comedy won the best directing trophy and Eric Stonestreet and Julie Bowen claimed supporting actor awards. There was at least a minor backlash online as some questioned whether the show had a deserving season.

    Stonestreet was funny and touching as he accepted for his role as half of a devoted gay couple.

    "I wouldn't be standing here without Jesse Tyler Ferguson, there is no Cam without Mitch," he said, saluting his co-star. "We get the awesome opportunity to play these two characters on TV and show America and the world what a loving couple we can be just like everybody else."

    Then he turned saucy: "I never knew I'd be on TV as a gay man, but I love the pictures of hairy chests you guys are sending me, it's really amazing. Thank you for those."

    Among reality competitors, "The Amazing Race" was honored as best reality series, ninth time in 10 nominations for the award. Tom Bergeron of "Dancing With the Stars" won as best host of a reality series.

    Julianne Moore's uncanny take on Gov. Sarah Palin in the TV movie "Game Change," about the 2008 presidential campaign, earned her best actress honors.

    "I feel so validated because Sarah Palin gave me a big thumbs down," Palin said, beaming.

    Kevin Costner was named best actor for the history-based miniseries "Hatfields & McCoys," while Tom Berenger was named best supporting actor for the project and Jessica Lange won supporting actress honors for "American Horror Story." ''Game Change" was crownd best series.

    "The Daily Show with Jon Stewart" proved unstoppable, winning its 10th consecutive best variety show trophy. Stewart, discussing the lasting value of his show, apparently forgot that what flies on free-wheeling cable gets censored on network television.

    "Years from now when the Earth is just a burning husk and aliens visit, they will find a box of these, and they will know, just how predictable these (several bleeps) can be," he said.

    Standup comic Louis C.K. won the Emmy for best comedy writing for "Louie" and for the special "Louis C.K. Live at the Beacon Theatre." Said the comedian after his second win: "Thank you to audiences around the country who still go to see live comedy."

    Kimmel, who played it clean, set up one of the night's best filmed comedy bits by musing on what "Breaking Bad" would have been like had it aired in a G-rated, pre-cable era.

    The answer: a spoof of the opening to "The Andy Griffith Show," with "Breaking Bad" stars Bryan Cranston and Aaron Paul, fully suited up to cook crystal meth, out at the lake with their fishing poles as the "Andy Griffith" whistling theme song was heard.

    As a pungent punchline, they shot dead an unexpected witness: a friendly deputy billed as co-star Don Knotts.

    The show started with bathroom humor: A filmed bit with Kathy Bates, Zooey Deschanel and other nominated actresses prepping in the restroom, then discovering a weeping Jimmy Kimmel lamenting a Botox reaction he said would keep him off stage as host.

    "You look beautiful," he was reassured. "You look like a 'Real Housewife.'"

    Viewers of the skit may have been puzzled by a nude Lena Dunham, the creator-star of "Girls," who's routinely brave about showing skin on the HBO comedy.

    Not all his material worked. One bit that fell flat had Kimmel's parents, or so the host said, escorted out of the theater because they promised he would win an Emmy and he didn't.

    "Family Guy" creator Seth MacFarlane found presenting can be tricky.

    "Oh, the mic's over there," he said, after discovering he was on the wrong side of the stage. "This is what happens when you don't come to rehearsal," MacFarlane said.

    Fashionistas noticed yellow was hot, the color of choice for Julianne Moore, a pregnant Danes, Julie Bowen and Hannah Simone from "New Girl."

    "Best hair and makeup goes to Danes. Perfect!" tweeted Emma Roberts.

    Emmy has to prove herself a winner with the audience. After rebounding somewhat to 13.5 million viewers in 2010 after an all-time low in 2008 of 12.3 million, last year's show drew 12.4 million viewers airing on Fox. The ceremony rotates annually among the four major networks.

    Source: http://www.philstar.com/Article.aspx?articleId=852323&publicationSubCategoryId=200

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    Monday, September 24, 2012

    Redskins' Kyle Shanahan takes blame for penalty

    ASHBURN, Va. (AP) ? Washington Redskins offensive coordinator Kyle Shanahan accepted responsibility Monday for his unsportsmanlike conduct penalty during the final confusing seconds of a loss to the Cincinnati Bengals.

    The son of head coach Mike Shanahan issued a written statement vowing that such an incident "will never happen again." Kyle Shanahan did not apologize in the statement, and the Redskins for the second straight day declined requests that he speak to reporters.

    NFL executive vice president of football operations Ray Anderson said he was reviewing Kyle Shanahan's actions from Sunday's game. Anderson has fined Denver Broncos head coach John Fox $30,000 and defensive coordinator Jack Del Rio $25,000 for verbally abusing officials during a Week 2 game, adding "there is a longstanding NFL rule prohibiting verbal or physical abuse of game officials."

    Shanahan was whistled for berating an official as the Redskins were attempting to drive for a tying touchdown in the 38-31 defeat. Robert Griffin III spiked the ball with 7 seconds remaining at Cincinnati's 34-yard line, and tight end Fred Davis was called for a false start as the offense lined up for the next play.

    At least one official apparently indicated ? erroneously ? that there would be a 10-second runoff because of the false start penalty, which would run out the clock. Cincinnati's coaches and players along the sideline then walked onto the field, thinking the game was over.

    That's when the Redskins coaching staff ? and Kyle Shanahan in particular ? went livid.

    "When I overheard the official tell the head coach that the game was over after the false start penalty, I tried to explain that the game was not over," Kyle Shanahan's statement said. "That is what resulted in the unsportsmanlike conduct penalty. I tried to get an explanation of how I could get that penalty when half of the other team was on the field as well.

    "I was frustrated, and in the process of trying to get some answers from the officials, I conducted myself in the wrong way. I ask our players to hold themselves to a high standard and be accountable and I know that I'm accountable for my actions as well. I know that I need to handle those situations better in the future. My emotions got the best of me and I know it's my responsibility. This will never happen again."

    The replacement officials ? who are handling the games while the regulars are locked out in a labor dispute with the NFL ? mistakenly marked off 20 yards for the penalty, instead of the customary 15. There was also the 5-yard penalty for the false start, so the ball ended up at Washington's 41, giving the Redskins a third-and-50, still with 7 seconds remaining.

    The game ended on the next play, with Griffin heaving an incomplete pass downfield.

    Asked if he was disappointed in his son's behavior, Mike Shanahan said: "He thought the game was over. ... The official told me that the game was over. We knew the game shouldn't be over. They had half their football team on the field. What I was trying to do was get a personal foul (called on Cincinnati). ... That wasn't the difference in winning and losing the game. You would like cooler heads to prevail and that's what I expect."

    Mike Shanahan added he wasn't exactly a picture of calm himself.

    "I'm not sure I was very cool in that situation," the head coach said. "I was very, very strong with my words with the official letting him know it wasn't the end of the game. Now is that cooler heads prevailing? Or are you trying to get one more play and explain what the rules are in the National Football League?"

    Asked if he thinks Kyle Shanahan should face league discipline, Mike Shanahan said: "I think we'll let the powers that be take a look at what transpired on both sides and let them make the decision."

    The Redskins have now drawn unsportsmanlike penalties in back-to-back games while trying to drive for a tying score, but Kyle Shanahan's explanation came a day late and in a different manner compared to the previous one.

    Receiver Joshua Morgan immediately accepted the blame for throwing the ball at cornerback Cortland Finnegan on Washington's final possession in a three-point loss to the St. Louis Rams a week earlier. The penalty turned a possible game-tying 47-yard field goal attempt into a 62-yard attempt that fell far short.

    "I should've kept my calm," Morgan told reporters in the locker room after the game.

    Asked if the coaching staff was setting a proper example for the players, Mike Shanahan said he doesn't think there should ever be an exception to his regular schedule that has his top assistants speaking to reporters only on Thursdays.

    "We've got a process that we work through," Mike Shanahan said. "And that's our process."

    ___

    Follow Joseph White on Twitter: http://twitter.com/JGWhiteAP

    ___

    Online: http://bigstory.ap.org/NFL-Pro32 and http://twitter.com/AP_NFL

    Source: http://news.yahoo.com/redskins-kyle-shanahan-takes-blame-penalty-173342550--nfl.html

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    Saturday, September 22, 2012

    Study shows ancient relations between language families

    ScienceDaily (Sep. 20, 2012) ? How do language families evolve over many thousands of years? How stable over time are structural features of languages?Researchers Dan Dediu and Stephen Levinson of the Max Planck Institute for Psycholinguistics in Nijmegen introduced a new method using Bayesian phylogenetic approaches to analyse the evolution of structural features in more than 50 language families.

    Their paper 'Abstract profiles of structural stability point to universal tendencies, family-specific factors, and ancient connections between languages' will be published online on Sept. 20 in PLoS ONE.

    Language is one of the best examples of a cultural evolutionary system. How vocabularies evolve has been extensively studied, but researchers know relatively little about the stability of structural properties of language -- pholonoly, morphology and syntax. In their PLoS ONE paper, Dan Dediu (MPI's Language and Genetics Department) and Stephen Levinson (director of MPI's Language and Cognition Department) asked how stable over time the structural features of languages are -- aspects like word order, the inventory of sounds, or plural marking of nouns.

    "If at least some of them are relatively stable over long time periods, they promise a way to get at ancient language relationships," the researchers state in their paper. "But opinion has been divided, some researchers holding that universally there is a hierarchy of stability for such features, others claiming that individual language families show their own idiosyncrasies in what features are stable and which not."

    Ancient relations between language families

    Using a large database and many alternative methods Dediu and Levinson show that both positions are right: there are universal tendencies for some features to be more stable than others, but individual language families have their own distinctive profile. These distinctive profiles can then be used to probe ancient relations between what are today independent language families.

    "Using this technique we find for instance probable connections between the languages of the Americas and those of NE Eurasia, presumably dating back to the peopling of the Americas 12,000 years or more ago," Levinson explains. "We also find likely connections between most of the Eurasian language families, presumably pre-dating the split off of Indo-European around 9000 years ago."

    Universal tendencies and distinctive profiles

    This work thus has implications for our understanding of differential rates of language change, and by identifying distinctive patterns of change it provides a new window into very old historical processes that have shaped the linguistic map of the world. It shows that there is no conflict between the existence of universal tendencies and factors specific to a language family or geographic area. It also makes the strong point that information about deep relationships between languages is contained in abstract, higher-level properties derived from large sets of structural features as opposed to just a few highly stable aspects of language. In addition, this work introduces innovative quantitative techniques for finding and testing the statistical reliability of both universal tendencies and distinctive language-family profiles.

    "Our findings strongly support the existence of a universal tendency across language families for some specific structural features to be intrinsically stable across language families and geographic regions," Dediu concludes.

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    Story Source:

    The above story is reprinted from materials provided by Max-Planck-Gesellschaft.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Dan Dediu, Stephen C. Levinson. Abstract Profiles of Structural Stability Point to Universal Tendencies, Family-Specific Factors, and Ancient Connections between Languages. PLoS ONE, 2012; 7 (9): e45198 DOI: 10.1371/journal.pone.0045198

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/mind_brain/child_development/~3/CzRTHBbl5C4/120920135321.htm

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    Friday, September 21, 2012

    UK shale gas can ease rising dependency on imports, says IoD

    LONDON (Reuters) - Britain must begin shale gas exploration to ease its growing dependency on imported gas, the Institute of Directors (IoD) said on Friday.

    Without the development of new domestic gas resources, Britain's import costs for natural gas could rise from $8.5 billion (5.2 billion pounds) today to more than $11 billion by 2015 as North Sea supplies dwindle and Norway struggles to fill the gap, Reuters research showed this week.

    Britain was a net exporter of gas until 2004, but a steady decline in output over the past few years has made it more reliant on imports, which have come mostly from Norway and, increasingly, Qatar.

    The only way to offset the effects of this increasing dependency on imports is to begin shale gas exploration in Britain, the IoD said in a report.

    "Shale gas development can counter falling North Sea production, halting the increase in gas imports," the business lobby group said. "It can also help to reduce price rises for consumers."

    In the United States, a shale gas boom has resulted in a sharp rise in natural gas production, leading to a collapse in domestic prices and the possibility of the U.S. exporting liquefied natural gas (LNG) by 2015.

    The British Geological Survey estimates Britain's onshore shale reserves at 5.3 trillion cubic feet (150 billion cubic metres), which would be enough to meet Britain's gas consumption for one and a half years, though UK shale gas exploration companies such as Cuadrilla Resources have put their figures as high as 200 trillion cubic feet.

    However, the IoD said that the development of a shale gas industry in Britain would not be on a scale comparable with North America and that Britain would still face several energy problems.

    "Shale gas development does not magically solve all the UK's energy issues," the report said. "North Sea production will still fall, the renewables programme will still increase energy prices for industry, and coal and nuclear will still decline in capacity.

    "A mix of power sources is vital, and domestic shale gas is unlikely to account for a majority of the UK's electricity generation, or even of its gas usage. But it could and should play an important role."

    The Institution of Mechanical Engineers also published a paper this week, saying that British shale gas reserves would not end the country's reliance on costly and unpredictable gas imports.

    ENVIRONMENTAL CONCERNS

    Shale gas production, known as fracking, is a controversial technology requiring the use of large amounts of water and chemicals. Environmental groups and large sections of the public oppose using the technology in western Europe, where population density is much higher than in North America.

    Bulgaria and France have both banned shale gas exploration. In Britain the technology has yet to receive full government approval.

    The IoD report said that the environmental issues associated with shale gas exploration "are not to be taken lightly", but that "good practice can significantly reduce many of these environmental risks".

    It also said that Britain had sufficient regulatory bodies to monitor and oversee the drilling process.

    "Carried out properly and under strict regulation, hydraulic fracturing is safe," the report said.

    In the long term, and to avoid the public debate that fracking causes onshore, some geologists say that fracking could move offshore to tap what are believed to be vast reserves in the North Sea.

    This, however, would be extremely costly and would require an oil price of far more than $200 a barrel to make it profitable. Analysts say that it would be a back-up option against an oil price spike rather than a viable option of gas supply in the mid-term future.

    (Editing by David Goodman)

    Source: http://news.yahoo.com/uk-shale-gas-ease-rising-dependency-imports-says-231906147--sector.html

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    New details emerge on Georgia teen found in L.A.

    DALLAS, Ga. (AP) ? An emaciated teenage Georgia boy told police he was forced to kneel for hours at a time by his stepfather and mother, who now face charges of child cruelty after allegedly confining the teen in a bedroom for years and then sending him by bus to Los Angeles to seek a homeless shelter.

    Investigators in Paulding County, Ga., conducted an afternoon search at the home where authorities allege Mitch Comer was kept in such seclusion that his two younger sisters in the same house did not know what he looked like.

    "The sisters haven't seen the brother in over two years," Paulding County sheriff's Cpl. Ashley Henson said. "They didn't even know what color his hair was."

    Stepfather Paul Comer and mother Sheila Comer face charges of false imprisonment and cruelty to children, Paulding County jail records show. They were being held without bond.

    Arrest warrants filed Sept. 12 and 13 in Georgia say the couple "made Mitch kneel on the floor, bend his head and place his forehead against the wall, and place his hands behind his head for long periods of time."

    The boy said he was fed small quantities of food daily, according to a Los Angeles police statement.

    Renee Rockwell, a lawyer for Sheila Comer, said her client is "standing by her not guilty plea."

    "I'm staying deep in prayer that the judge sees fit to grant her bond," Rockwell said.

    "We're doing our own independent investigation right now, and Paul is helping with that," said Paul Comer's lawyer Scott Smith. "He's deeply concerned about the seriousness of the charges against him."

    Smith said he couldn't comment further but that his client is looking forward to his bond hearing Oct. 4.

    The FBI and the Georgia Bureau of Investigation have joined the case, Henson said.

    Mitch Comer told police his stepfather gave him $200 and a list of homeless shelters before he was put on a bus to Los Angeles on this 18th birthday, police in Los Angles said Thursday.

    Retired Los Angeles police Sgt. Joe Gonzalez was working security at a downtown bus station Sept. 11 when he spotted the 87-pound teenage boy who stood just over 5 feet tall and looked much younger, Los Angeles police said in a statement Thursday.

    The boy told Gonzalez his stepfather declared that he was now a man before putting the teen on a bus.

    Because he was so childlike, police worried that he wasn't as old as he claimed and decided to investigate further. The teen told authorities he had suffered years of abuse after being taken out of school in the eighth grade.

    Paul Comer had his own business repairing home appliances, said next-door neighbor John White. They rarely spoke.

    Comer's wife never left the house unless she was with her husband, not even to check the mail, White said. Their two daughters would sometimes come outside and play, but only in the back yard. Neighbors assumed the girls didn't go to school either ? they never caught the bus that picked up other children in the cul-de-sac every morning.

    Neighbors said they had no clue the Comers had a son until a detective came knocking at their doors asking questions last week.

    "I had no idea, no clue. There were no signs of a son at all," said Dion Walker, who's lived next to the Comers for two years. "The few occasions we would see them go to the van, it was always the parents and the two girls."

    She said her 8-year-old daughter would occasionally play with the Comer girls, who she initially thought were the same age as her own daughter. They were the same size and seemed to have the same maturity level. However, she said police later told her the Comer girls were 11 and 13.

    Walker said the Comer family did not take part in neighborhood association meetings and their girls never attended the neighborhood Halloween block parties.

    "We said one day, why don't you come over here? And they said their father would not let them cross the yard. So from that point I stopped letting my daughter go over there. And they would just stare at us."

    Walker said police swarmed the Comers' home last week, arresting the parents and taking both girls into protective custody.

    Source: http://news.yahoo.com/details-emerge-georgia-teen-found-l-182012023.html

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    Drive Targeted Traffic To Your Online Affiliate Marketing Business ...

    ?

    By William Morgan

    Twitter can be used to drive targeted traffic to your online affiliate marketing business.

    The important thing to remember here is not to over self-promote. You want to create a balance between self-promotion and sharing information that isn?t always yours. Over self-promoting is frowned upon on Twitter. However if you continually share information that provides value to your followers and occasionally link to self-promoting resources, twitter can become a very valuable asset to your business.

    Provide value and your online affiliate marketing business will flourish. When people realize that you are providing value to them they will regularly start following your links. It?s important to remember that Twitter and blogging go hand-in-hand. Twitter has changed the way people communicate online, and therefore should be included in your overall marketing plan. As powerful as twitter can be for your online affiliate marketing business it is still free to join, and you can set up an account in minutes.

    Twitter is very simple to understand and really only has two main components, getting followers and you following other people. Your followers will receive your updates and you in return will receive all their updates. Twitter is often referred to as micro-blogging, because your messages are limited to just one hundred and 40 characters. Sending and receiving messages that are brief and right to the point is a fun experience, that doesn?t take up very much time.

    You must choose your words wisely if you expect to get your point across and just 140 characters, say what you want to say in such a small space I believe is a major reason why Twitter has become such a popular social media.

    When using Twitter for your online affiliate marketing business always try to think out of the box. Use the search feature and twitter to find people with similar interests to yours, and then follow them. Many times they will follow you back, don?t ignore them, when someone follows you be certain to communicate with them by sending them a direct message.

    Twitter is a great website traffic builder that you?ll want to use in your online affiliate marketing business you can get quality traffic by sending messages (tweets) that are valuable and helpful to your followers. Twitter users come from all over the world, and communicating with people in other countries can be intriguing.

    As you add followers, and as they start following you back slowly you will get to know each other, and a communication line has been developed. In business this can be a huge asset, for example if you need a favor, you can send out a tweet asking your followers for help. You never know who can help you, or who knows someone that you can get help from.

    What is re-tweeting? A re-tweet is what is called when someone takes a message you sent and then sends it to their followers. Very similar to forwarding e-mail. When you send a valuable tweet to your followers, request that they re-tweeted so that it gets passed on to their followers. If your message is interesting enough it will become viral, and if it contains a link to your website, you?re golden. Your online affiliate marketing business will now receive all those back links,

    in your online affiliate marketing business can drive unlimited amounts of targeted traffic to your business. It?s fun and easy to use and costs absolutely nothing. Don?t over self-promote, focus on providing value to your followers.Learn how use Twitter
    Regards
    William Morgan

    Source: http://internet-millionaire-articles.com/drive-targeted-traffic-to-your-online-affiliate-marketing-business-website-with-twitter/

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    Thursday, September 20, 2012

    Actress in anti-Muslim movie sues filmmaker for fraud

    LOS ANGELES, Calif. - An actress who appears in the anti-Muslim film that has sparked riots in the Middle East is suing the filmmaker for fraud and slander and suing Google to try to get the movie's trailer removed online.

    Cindy Lee Garcia's lawsuit filed Wednesday in Los Angeles claims the actress was duped by Nakoula Basseley Nakoula, the man behind "Innocence of Muslims" who has been forced into hiding since its 14-minute trailer rose to prominence last week. She was unaware of the film's anti-Muslim content and said the pages of the script she received had no mention of the prophet Muhammad, according to her complaint.

    The lawsuit states Garcia responded to an ad and thought she was appearing in an ancient Egyptian adventure film, which was altered to give it an anti-Islamic message.

    "The film is vile and reprehensible," Garcia's attorney, M. Cris Armenta, wrote in the document.

    "This lawsuit is not an attack on the First Amendment nor on the right of Americans to say what they think, but does request that the offending content be removed from the Internet," the complaint states. Garcia's attorneys plan to seek an injunction against the film Thursday in a Los Angeles court.

    Garcia has received death threats since the trailer began drawing attention, and her suit states she no longer is able to visit her grandchildren as a result. It has also harmed her reputation and caused "shame, mortification, and hurt feelings," the suit states.

    An email sent to Google seeking comment was not immediately returned. The search giant owns YouTube and has blocked users in Saudi Arabia, Libya and Egypt from viewing the "Innocence of Muslims" trailer. It has also blocked the video from being viewed in Indonesia and India because it violates laws in those countries.

    A man who answered the phone at the law offices of Steven Seiden, who represents Nakoula on any criminal repercussions he may face, declined comment. He said Seiden does not represent Nakoula, who is on probation for a bank fraud case in which he opened 600 fraudulent credit accounts, in civil matters.

    According to the terms of his probation, Nakoula was allowed to only access websites with the permission of probation officials and for work purposes. It is unclear who uploaded the film to the site.

    The lawsuit also names Sam Bacile, an alias that Nakoula gave to The Associated Press after the trailer was linked to protests that have since killed at least 30 people in seven countries, including the U.S. ambassador to Libya.

    ___

    Anthony McCartney can be reached at http://twitter.com/mccartneyAP

    Source: http://news.yahoo.com/actress-anti-muslim-movie-sues-removal-online-sues-210730326.html

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    Friday, September 7, 2012

    US productivity grew at 2.2% rate in spring

    "; /////////////////////////////////////////////////////////////////////////////////// function display_postings() { // Handle no postings situation if (allPostings.length == 1) { document.write(header); document.write("

    Watch for Top Jobs coming to this space soon.

    "); document.write(""); return; } if (!FORM_DATA['topjobscount']) { if (!topjobs_count) { var displayCount = 5; } else { var displayCount = topjobs_count; } } else { var displayCount = FORM_DATA['topjobscount']; } // Create target array var displayPostings; var allPostingsCount = allPostings.length; var i; if (displayCount == 99999) { document.write(allHeader); // Remember array entry 0 is placeholder, so start at index 1 for (i = 1; i

    " + allPostings[i][0] + "
    " + allPostings[i][2] + "

    "); } else { document.write("

    " + allPostings[i][0] + "
    " + allPostings[i][1] + "

    "); } } document.write(allFooter); } else { // Delete array entry 0 ("placeholder") for (i = 0; i 0 && allPostingsCount > 0) { // Move a random entry from allPostings to displayPostings var targetIndex = Math.floor(Math.random() * allPostingsCount % allPostingsCount); displayPostings[displayPostings.length] = allPostings[targetIndex]; for (i = targetIndex; i

    " + displayPostings[i][0] + "

    "); } } // Display Employer Name only. If Employer name does not exist display Job Title else if (topjobs_option == 2) { for (i = 0; i

    " + displayPostings[i][0] + "

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    " + displayPostings[i][0] + "
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    "); } } } // Display Job Title followed by Job Description else if (topjobs_option == 5) { for (i = 0; i

    " + displayPostings[i][0] + "
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    " + displayPostings[i][2] + "
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    "); } else { document.write("

    " + displayPostings[i][1] + "
    " + displayPostings[i][0] + "

    "); } } } // Display Employer Name followed by Job Description. If Employer name does not exist display Job Title else if (topjobs_option == 7) { for (i = 0; i

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    " + displayPostings[i][2] + "

    "); } else { document.write("

    " + displayPostings[i][1] + "
    " + displayPostings[i][2] + "

    "); } } } // Display Job Description followed by Job Title else if (topjobs_option == 8) { for (i = 0; i

    " + displayPostings[i][2] + "
    " + displayPostings[i][0] + "

    "); } } // Display Job Description followed by Employer Name. If Employer name does not exist display Job Title else if (topjobs_option == 9) { for (i = 0; i

    " + displayPostings[i][2] + "
    " + displayPostings[i][0] + "

    "); } else { document.write("

    " + displayPostings[i][2] + "
    " + displayPostings[i][1] + "

    "); } } } // Default to Job Title followed by Employer Name. If Employer name does not exist display Job Description else { for (i = 0; i

    " + displayPostings[i][0] + "
    " + displayPostings[i][2] + "

    "); } else { document.write("

    " + displayPostings[i][0] + "
    " + displayPostings[i][1] + "

    "); } } } document.write(footer); } } function createRequestObject() { return 1 // The Object (Array) where our data will be stored. separator = ','; // The token used to separate data from multi-select inputs query = '' + this.location; qu = query // Get the current URL so we can parse out the data. // Adding a null-string '' forces an implicit type cast // from property to string, for NS2 compatibility. query = query.substring((query.indexOf('?')) + 1); // Keep everything after the question mark '?'. if (query.length -1) { keypairs[numKP] = query.substring(0,query.indexOf('&')); query = query.substring((query.indexOf('&')) + 1); numKP++; // Split the query string at each '&', storing the left-hand side // of the split in a new keypairs[] holder, and chopping the query // so that it gets the value of the right-hand string. } keypairs[numKP] = query; // Store what's left in the query string as the final keypairs[] data. for (i in keypairs) { keyName = keypairs[i].substring(0,keypairs[i].indexOf('=')); // Left of '=' is name. keyValue = keypairs[i].substring((keypairs[i].indexOf('=')) + 1); // Right of '=' is value. while (keyValue.indexOf('+') > -1) { keyValue = keyValue.substring(0,keyValue.indexOf('+')) + ' ' + keyValue.substring(keyValue.indexOf('+') + 1); // Replace each '+' in data string with a space. } keyValue = unescape(keyValue); // Unescape non-alphanumerics if (FORM_DATA[keyName]) { FORM_DATA[keyName] = FORM_DATA[keyName] + separator + keyValue; //document.write('The value of ' +keyName+ ' is:'+FORM_DATA[keyName]+'
    '); // Object already exists, it is probably a multi-select input, // and we need to generate a separator-delimited string // by appending to what we already have stored. } else { FORM_DATA[keyName] = keyValue; //document.write('The value of ' +keyName+ ' is:'+FORM_DATA[keyName]+'
    '); // Normal case: name gets value. } } return FORM_DATA; } // MAINLINE FORM_DATA = createRequestObject(); // This is the array/object containing the GET data. // Retrieve information with 'FORM_DATA [ key ] = value'. // Display jobs display_postings();

    GannettCopyright ? 2012 azcentral.com. All rights reserved.
    Users of this site agree to the , and Ad Choices

    Source: http://www.azcentral.com/business/articles/2012/09/05/20120905us-productivity-grew-rate-spring.html

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    Board of Supervisors proposal could have Athletics Department give $7.2 million a year to University

    The LSU System Board of Supervisors will deliberate Friday whether LSU Athletics should help tackle the University?s ongoing budget crisis.

    If passed, the LSU Athletics Fund Transfer Policy would create an annual transfer of $7.2 million dollars from the Athletics Department to the University for five years, totalling of $36 million. The money would fund academics, research, public service and allow the University to have more certainty when developing operating budgets, according to Interim System President and Chancellor William ?Bill? Jenkins.

    ?For the first time in a long time, we?d have discretionary funds that we can use for key matters,? Jenkins said. ?We would be able to invest in students and faculty.?

    Along with the annual $7.2 million, the policy also allows for funding to go to the University if LSU Athletics makes a surplus of money.

    Of any surplus between $3-5 million, 25 percent will be transferred to the University. If a surplus exceeds $5 million, 50 percent of the funds will be transferred to the University. The policy will also provide a one-time donation of $4 million to the University for the fiscal year.

    Over the past four years, the state has cut 43.6 percent from the University?s appropriations. To offset the cuts, the University has upped self-generated funds by $103.15 million, or more than 54 percent, spearheaded by increases in tuition.

    LSU Athletics pitched in to close the budget gap, most recently donating $5.5 million after cuts this year ? $4 million to protect the University?s academic core and a $1.5 million permanent contribution to fund the Cox Academic Center for Student Athletes.

    In 2011, the Board of Supervisors approved a $7.9 million LSU System Flagship and Excellence Fund, one-time additional support for the University using self-generated money and interest earnings.

    ?I am not aware of another university that has something like this,? Jenkins said. ?I believe it?s unique. The success of athletics will impact the success of academics.?

    ____
    Contact Chris Grillot at cgrillot@lsureveille.com
    ?

    Source: http://www.lsureveille.com/news/board-of-supervisors-proposal-could-have-athletics-department-give-7-2-million-a-year-to-university-1.2757607

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    Thursday, September 6, 2012

    Kindle Serials Brings Back Dickensian-Style Book Installments [Kindle]

    Back when Charles Dickens and his cohorts were publishing, books didn't come fully formed; instead, they came out in regular installments; that's why each chapter tends to end with a cliffhanger. Today, Amazon announced that it's bringing that proud tradition back with Kindle Serials. More »


    Source: http://feeds.gawker.com/~r/gizmodo/full/~3/yHfELBPbsyA/kindle-serials-brings-back-dickensian+style-book-installments

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    Wednesday, September 5, 2012

    Mouse study suggests sleep problems may be early Alzheimer's sign

    ScienceDaily (Sep. 5, 2012) ? Sleep disruptions may be among the earliest indicators of Alzheimer's disease, scientists at Washington University School of Medicine in St. Louis report Sept. 5 in Science Translational Medicine.

    Working in a mouse model, the researchers found that when the first signs of Alzheimer's plaques appear in the brain, the normal sleep-wake cycle is significantly disrupted.

    "If sleep abnormalities begin this early in the course of human Alzheimer's disease, those changes could provide us with an easily detectable sign of pathology," says senior author David M. Holtzman, MD, the Andrew B. and Gretchen P. Jones Professor and head of Washington University's Department of Neurology. "As we start to treat Alzheimer's patients before the onset of dementia, the presence or absence of sleep problems may be a rapid indicator of whether the new treatments are succeeding."

    Holtzman's laboratory was among the first to link sleep problems and Alzheimer's through studies of sleep in mice genetically altered to develop Alzheimer's plaques as they age. In a study published in 2009, he showed that brain levels of a primary ingredient of the plaques naturally rise when healthy young mice are awake and drop after they go to sleep. Depriving the mice of sleep disrupted this cycle and accelerated the development of brain plaques.

    A similar rising and falling of the plaque component, a protein called amyloid beta, was later detected in the cerebrospinal fluid of healthy humans studied by co-author Randall Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology at Washington University.

    The new research, led by Jee Hoon Roh, MD, PhD, a neurologist and postdoctoral fellow in Holtzman's laboratory, shows that when the first indicators of brain plaques appear, the natural fluctuations in amyloid beta levels stop in both mice and humans.

    "We suspect that the plaques are pulling in amyloid beta, removing it from the processes that would normally clear it from the brain," Holtzman says.

    Mice are nocturnal animals and normally sleep for 40 minutes during every hour of daylight, but when Alzheimer's plaques began forming in their brains, their average sleep times dropped to 30 minutes per hour.

    To confirm that amyloid beta was directly linked to the changes in sleep, researchers gave a vaccine against amyloid beta to a new group of mice with the same genetic modifications. As these mice grew older, they did not develop brain plaques. Their sleeping patterns remained normal and amyloid beta levels in the brain continued to rise and fall regularly.

    Scientists now are evaluating whether sleep problems occur in patients who have markers of Alzheimer's disease, such as plaques in the brain, but have not yet developed memory or other cognitive problems.

    "If these sleep problems exist, we don't yet know exactly what form they take -- reduced sleep overall or trouble staying asleep or something else entirely," Holtzman says. "But we're working to find out."

    Share this story on Facebook, Twitter, and Google:

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    Story Source:

    The above story is reprinted from materials provided by Washington University in St. Louis. The original article was written by Michael C. Purdy.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. J. H. Roh, Y. Huang, A. W. Bero, T. Kasten, F. R. Stewart, R. J. Bateman, D. M. Holtzman. Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of ?-Amyloid in Mice with Alzheimer's Disease Pathology. Science Translational Medicine, 2012; 4 (150): 150ra122 DOI: 10.1126/scitranslmed.3004291

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/TZhw22lao0s/120905141614.htm

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